Carnosinase Inhibitors

Recently, Wake Forest University Baptist Medical Center and University of Heilderberg have found the existence of genes that contribute to the occurrence of chronic kidney disease (PGK) in patients with diabetes. As with known diabetes had the greatest cause of chronic kidney disease.


One of the initiators of dr.Fredman said that this has been 20 years done the search for genes that play a role in diabetes nephropati.

This gene named carnosinase 1 is located on chromosome 8. This carnosinase gene produces an enzyme called carnosinase; carnosinase contains 5 leucine/5leucine and called CNDP1 Manheim. It broke Carnosinase and menginaktifkan protective effects of carnosine. Carnosine is an enzyme that acts to have a protective effect on kidney tissue damage and as a destroyer of free radicals.

A study of 242 European white people found that those who have low levels carnosinase was better protected against the incidence of diabetes nephropati.

Based on the above, the potential of new therapies and markers for diabetes nephropati currently possible. Carnosinase inhibitors currently being tested in Germany. Currently evaluated whether the provision should carnosine or carnosinase inhibitors that will protect nephropati progression of diabetes.

Source: Kalbefarma | 26-Jan-2007 | By: DHS Medical